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Related Experiment Video

Updated: Jun 21, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Multiple loci comprising immune-related genes regulate experimental neuroinflammation.

M Marta1, P Stridh, K Becanovic

  • 1Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Monica.Marta@ki.se

Genes and Immunity
|August 14, 2009
PubMed
Summary
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Researchers identified four genetic regions (QTLs) on rat chromosome 4 that influence experimental autoimmune encephalomyelitis (EAE). These QTLs regulate disease susceptibility and severity, offering insights into the complex genetic basis of EAE and potentially multiple sclerosis (MS).

Area of Science:

  • Immunology
  • Genetics
  • Neuroscience

Background:

  • Experimental autoimmune encephalomyelitis (EAE) is a model for multiple sclerosis (MS).
  • A specific region on rat chromosome 4 is known to influence EAE.
  • Understanding the genetic regulation of EAE is crucial for developing new therapies.

Purpose of the Study:

  • To genetically dissect a 58 Mb region on rat chromosome 4 regulating EAE.
  • To identify and characterize quantitative trait loci (QTLs) within this region.
  • To investigate the role of these QTLs in disease susceptibility, severity, and immune response.

Main Methods:

  • High-resolution linkage analysis in an advanced intercross line (AIL).
  • Analysis of humoral immune response, including anti-myelin oligodendrocyte glycoprotein (MOG) antibody levels.

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Last Updated: Jun 21, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Targeted Knockdown of Genes in the Choroid Plexus
04:43

Targeted Knockdown of Genes in the Choroid Plexus

Published on: June 16, 2023

  • Testing of parental and recombinant congenic strains in MOG-EAE models.

    • Main Results:

    • Four QTLs (Eae24-Eae27) were identified, regulating EAE susceptibility and/or severity.
    • Eae24 and Eae25 protected during the acute phase; Eae25 and Eae26 modified severity.
    • A minimal congenic fragment with Eae25 alone influenced susceptibility, severity, and protected from chronic EAE.

    Conclusions:

    • Multiple QTLs contribute to the polygenic regulation of MOG-EAE.
    • These findings advance the understanding of EAE pathogenesis and its relevance to MS.
    • The identified QTLs provide opportunities for comparative genetics and testing in MS cohorts.