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Use of bisphosphonates in prostate cancer: Current status

Rishi Nayyar1, Narmada P Gupta

  • 1Department of Urology, All India Institute of Medical Sciences, New Delhi - 110 029, India.

Indian Journal of Urology : IJU : Journal of the Urological Society of India
|August 14, 2009
PubMed

Insights

Bisphosphonates help prevent bone complications in osteoporosis and cancers like breast cancer and multiple myeloma. Their use in prostate cancer management is still being studied through ongoing clinical trials.

Area of Science:

  • Oncology
  • Pharmacology
  • Bone Metabolism

Background:

  • Bisphosphonates are established treatments for skeletal complications in osteoporosis, breast cancer, and multiple myeloma.
  • Their efficacy and optimal use in prostate cancer management remain under investigation.

Purpose of the Study:

  • To review current randomized trials on bisphosphonates in prostate cancer.
  • To define the role of bisphosphonates across different stages of prostate cancer.

Main Methods:

  • Systematic review of published and ongoing randomized controlled trials.
  • Analysis of bisphosphonate use in various prostate cancer contexts.

Main Results:

  • Data from ongoing and published trials are being synthesized.
  • The evolving role of bisphosphonates in prostate cancer is being defined.

Conclusions:

  • Bisphosphonates show promise in managing prostate cancer-related bone issues.
  • Further research will clarify their definitive role in prostate cancer therapy.
Keywords:
Bisphosphonateshormone resistant prostate cancerprostate cancer

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