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Published on: February 3, 2012
Vaccination as a triggering event for autoimmune hepatitis
Ponni Perumalswami1, Lan Peng, Joseph A Odin
1Division of Liver Diseases, Department of Medicine, The Mount Sinai Medical Center, New York, New York 10029, USA.
Abstract:
The pathogenesis of autoimmune hepatitis entails complex interactions between triggering factors, autoantigens, genetic predisposition, and immunoregulatory networks. Implicated triggering factors are numerous and include toxins, medications, and infectious agents. In this article, we present a unique case of a 31-year-old woman with severe autoimmune hepatitis apparently abruptly triggered by vaccination. All evidence suggests this was an idiosyncratic response to either hepatitis A or yellow fever vaccination.
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