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Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer
1Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Lancet (London, England)
|January 27, 1990
Abstract:
Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formation.