Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence, pattern and prognosis of lung lesions in pediatric Hodgkin lymphoma.

Scientific reports·2026
Same author

Statement by the Uterus Commission of the Arbeitsgemeinschaft Gynäkologische Onkologie [German Gynecological Oncology Group] (AGO) on the ESGO-ESTRO-ESP Guideline 2025.

Geburtshilfe und Frauenheilkunde·2026
Same author

Expert opinion : Radiotherapy in cutaneous squamous cell carcinoma: Recommendations from the DEGRO dermatooncology working group.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2026
Same author

Stereotactic ablative radiotherapy versus video-assisted lobectomy for operable stage I non-small-cell lung cancer: study protocol for an emulated target trial.

BMJ open·2026
Same author

Relevance of the Radon space shadow zone in coplanar and non-coplanar volumetric modulated arc therapy: studies on head and neck and geometrical targets.

Physics in medicine and biology·2026
Same author

KORT - Knee osteoarthrosis radiotherapy trial: Protocol for a multidisciplinary pathway and a planned sham-controlled phase III trial of low-dose radiotherapy in knee osteoarthritis.

Osteoarthritis and cartilage open·2026
Same journal

Can intracochlear voltage matrix analysis explain the occurrence of electrically evoked vestibular responses in cochlear implant users?

Zeitschrift fur medizinische Physik·2026
Same journal

Limitations of Mono-Exponential Individual Fitting as a Reference Model for Single-Time-Point Dosimetry in [<sup>177</sup>Lu]Lu-PSMA-617 Therapy.

Zeitschrift fur medizinische Physik·2026
Same journal

Determination of long-range resistance from high resolution impedance spectroscopy in human cadaveric heads.

Zeitschrift fur medizinische Physik·2026
Same journal

Patient-specific quality assurance in stereotactic radiotherapy: clinical practice in absence of guidelines - status and new approach from the DGMP working group for physics and technology in stereotactic radiotherapy.

Zeitschrift fur medizinische Physik·2026
Same journal

Potential and challenges of Positron Emission Tomography beyond conventional preclinical and clinical imaging.

Zeitschrift fur medizinische Physik·2026
Same journal

Evaluation of PET/CT Artificial Intelligence Image Reconstructions VS Harmonized Clinical Reconstruction.

Zeitschrift fur medizinische Physik·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Steep dose gradients for simultaneous integrated boost IMRT.

Klaus Bratengeier1, Jürgen Meyer, Franz Schwab

  • 1Universität Würzburg, Klinik und Poliklinik für Strahlentherapie, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany. Bratengeie_K@klinik.uni-wuerzburg.de

Zeitschrift Fur Medizinische Physik
|August 15, 2009
PubMed
Summary
This summary is machine-generated.

Two-step intensity modulated radiotherapy (IMRT) effectively creates steep dose gradients needed for simultaneous integrated boosts (SIB). This new method improves dose homogeneity and spares surrounding tissues compared to commercial systems.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Related Experiment Videos

Last Updated: Jun 21, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Area of Science:

  • Radiation oncology
  • Medical physics
  • Radiotherapy technology

Background:

  • Intensity modulated radiotherapy (IMRT) algorithms are crucial for precise radiation delivery.
  • Simultaneous integrated boosts (SIB) require steep dose gradients between distinct planning target volumes (PTVs).
  • Current IMRT algorithms may not optimally address the geometric challenges of SIB.

Purpose of the Study:

  • To analyze the geometry of the SIB problem in IMRT.
  • To develop and implement a novel algorithm, two-step intensity modulated radiotherapy (2-Step IMRT), for generating IMRT segments.
  • To evaluate the efficacy of 2-Step IMRT in achieving steep dose gradients for SIB.

Main Methods:

  • Derived mathematical relationships based on dose levels and PTV diameters.
  • Implemented these relationships into the 2-Step IMRT algorithm for segment generation.
  • Compared the results of 2-Step IMRT with a commercial IMRT planning system.

Main Results:

  • 2-Step IMRT generated equivalent or superior results compared to the commercial system.
  • Achieved improved dose homogeneity in both the inner and outer PTVs.
  • Demonstrated lower composite objective values and reduced segment numbers, leading to better sparing of surrounding tissues.

Conclusions:

  • 2-Step IMRT is a viable method for achieving steep dose gradients required for SIB.
  • The developed algorithm offers advantages in dose distribution and tissue sparing.
  • This approach enhances the capabilities of IMRT for complex treatment scenarios like SIB.