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Alkaloids from Sternbergia colchiciflora.

Strahil Berkov¹, Jaume Bastida, Reneta Tsvetkova

¹Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Catalonia, Spain.

Zeitschrift Fur Naturforschung. C, Journal of Biosciences

|August 15, 2009

Summary

Sternbergia colchiciflora contains 21 alkaloids, with 10 isolated and identified. Alkaloid profiles vary with the plant

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Area of Science:

Phytochemistry
Natural Products Chemistry
Pharmacognosy

Background:

Sternbergia colchiciflora (Amaryllidaceae) is a plant species previously unstudied for its chemical constituents.
Alkaloids are a significant class of natural products known for diverse biological activities.

Purpose of the Study:

To investigate the alkaloid composition of Sternbergia colchiciflora.
To analyze variations in alkaloid profiles throughout the plant's phenological cycle.

Main Methods:

Gas Chromatography-Mass Spectrometry (GC-MS) for detection of alkaloids in crude extracts.
Isolation and purification of alkaloids.
Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), and Circular Dichroism (CD) for structural elucidation.

Main Results:

Twenty-one alkaloids and related compounds were identified in Sternbergia colchiciflora.
Ten alkaloids were isolated and their structures confirmed.
Significant variations in alkaloid patterns were observed during different phenological stages.
Lycorine-type alkaloids were dominant during flowering and dormancy.
Haemanthamine-type alkaloids predominated in leaves during development, while lycorine-type compounds were found in bulbs during fructification.

Conclusions:

Sternbergia colchiciflora is a rich source of diverse alkaloids, including known bioactive compounds like lycorine, tazettine, and haemanthidine.
The alkaloid profile of the plant is dynamic and influenced by its phenological stage.
Understanding these variations is crucial for potential applications and further research into the plant's medicinal properties.