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Adrenergic urticaria and adrenergic pruritus
1Department of Dermatology, School of Medicine, Karl Marx University, Leipzig, German Democratic Republic.
Acta Dermato-Venereologica
|January 1, 1990
Summary
Adrenergic urticaria and pruritus are linked to stress-induced increases in noradrenaline and adrenaline. Symptoms were reproducible by intradermal injections and successfully treated with beta-blockers.
Area of Science:
- Dermatology
- Endocrinology
- Pharmacology
Background:
- Adrenergic urticaria is a rare condition.
- Distinguishing it from cholinergic urticaria is important.
- Adrenergic pruritus may be a variant of adrenergic urticaria.
Observation:
- Two patients presented with adrenergic urticaria and pruritus.
- Lesions and symptoms correlated with stress and increased plasma levels of noradrenaline, adrenaline, and prolactin.
- Dopamine levels were elevated only in the adrenergic urticaria case.
Findings:
- Intradermal injections of adrenaline and noradrenaline reproduced the symptoms.
- Propranolol, a beta-adrenergic receptor blocker, effectively treated the symptoms.
- Elevated stress hormones (noradrenaline, adrenaline) are implicated in these conditions.
Implications:
- Adrenergic urticaria is a distinct dermatological entity.
- Understanding the role of adrenergic pathways in urticaria is crucial for diagnosis and treatment.
- Beta-blocker therapy shows promise for managing adrenergic urticaria and pruritus.