Restless legs syndrome: diagnostic time-savers, Tx tips
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Updated: Jun 21, 2026

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
Darlene E Moyer1, Javier Zayas-Bazan, Gary Reese
1Scottsdale Healthcare Family Medicine Residency Program, University of Arizona School of Medicine, 7301 East 2nd Street, Scottsdale, AZ 85251, USA. darlene.moyer@gmail.com
Abstract:
To diagnose restless legs syndrome (RLS), start with the 4 "essential criteria": (1) a powerful urge to move the legs that is (2) rest-induced, (3) improves with activity, and (4) worsens in the evening. Carefully screen for secondary causes of RLS, including renal failure, pregnancy, iron deficiency, and medications that can cause or exacerbate symptoms. Carbidopa/levodopa is the first-line treatment for patients with intermittent symptoms of RLS; dopamine agonists are recommended for those with daily or refractory symptoms.
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