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Updated: Jun 21, 2026
09:40
Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
Published on: September 28, 2018
Out of the box binding determines specificity of SH2 domain interaction
Structure (London, England : 1993)
|August 15, 2009
Abstract:
SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.
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