Related Experiment Video

Updated: Jun 21, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Control of pertussis--lessons learnt from a 10-year surveillance programme in Sweden

Rose-Marie Carlsson1, Birger Trollfors

  • 1Centre for Defence Medicine, Swedish Armed Forces, Box 5155, S-426 05 Västra Frölunda, Sweden. rose-marie.carlsson@mil.se

Vaccine
|August 15, 2009
PubMed

Insights

Sweden

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Sweden uniquely lacked general pertussis vaccination upon acellular pertussis (aP) vaccine introduction.
  • aP vaccines have been administered since 1996 at 3, 5, and 12 months with 99% coverage.
  • A 10-year enhanced surveillance project monitored long-term aP vaccine effects.

Purpose of the Study:

  • To evaluate the long-term effectiveness of acellular pertussis (aP) vaccines in Sweden.
  • To assess the impact of aP vaccination on pertussis incidence and severity in children.
  • To inform future pertussis control strategies.

Main Methods:

  • Long-term surveillance of pertussis incidence and vaccination status.
  • Analysis of hospitalization data and mortality related to pertussis.
  • International workshop to discuss surveillance findings.

Main Results:

  • aP vaccines significantly reduced pertussis burden in preschool children.
  • Unvaccinated infants or those with single-dose vaccination had the highest incidence.
  • Most hospitalizations and eight infant deaths occurred in unvaccinated infants.

Conclusions:

  • The Swedish aP vaccination program successfully reduced pertussis in young children.
  • Further strategies are necessary to mitigate morbidity from circulating Bordetella pertussis.
  • High vaccine coverage is crucial for controlling pertussis.

More Related Videos

Experimental Human Pneumococcal Carriage07:47

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

Related Concept Videos

Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis: