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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Hemoglobin-based red blood cell substitutes and nitric oxide
Binglan Yu1, Kenneth D Bloch, Warren M Zapol
1Anesthesia Center for Critical Care Research of the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Trends in Cardiovascular Medicine
|August 15, 2009
Summary
Inhaling nitric oxide (NO) before hemoglobin-based oxygen carriers (HBOCs) infusion prevents dangerous blood pressure increases. This strategy also avoids lung constriction, improving HBOCs
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Respiratory Physiology
Background:
- Hemoglobin-based oxygen carriers (HBOCs) are investigated as blood substitutes.
- HBOCs cause vasoconstriction by scavenging nitric oxide (NO), limiting clinical use.
- Systemic hypertension and pulmonary vasoconstriction are adverse effects of HBOC infusion.
Purpose of the Study:
- To evaluate the efficacy of inhaled nitric oxide (NO) in mitigating HBOC-induced adverse effects.
- To determine if NO inhalation can prevent systemic hypertension and pulmonary vasoconstriction.
- To assess the impact of concurrent NO inhalation on plasma methemoglobinemia.
Main Methods:
- Administration of low-dose nitric oxide (NO) by inhalation prior to HBOC infusion.
- Monitoring of systemic blood pressure and pulmonary arterial pressure.
- Measurement of plasma methemoglobin levels.
Main Results:
- Inhaled NO prevented systemic hypertension associated with HBOC infusion.
- Concurrent NO inhalation mitigated pulmonary vasoconstriction post-HBOC infusion.
- NO inhalation did not increase plasma methemoglobinemia.
Conclusions:
- Inhaled nitric oxide is a viable strategy to counteract HBOC-induced vasoconstriction.
- This approach enhances the safety profile of hemoglobin-based oxygen carriers.
- NO inhalation offers a promising method to improve HBOC clinical applications.
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