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Published on: August 28, 2018
Characterization of complex coronary artery stenosis morphology by coronary computed tomographic angiography
Brett M Wertman1, Victor Y Cheng, Saibal Kar
1Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Insights
Coronary computed tomography angiography (CTA) can identify complex coronary artery stenosis and predict lesions requiring intervention. This imaging technique helps assess percutaneous coronary intervention (PCI) risk and procedural complexity.
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
- Radiology
Background:
- Stenosis morphology complexity impacts percutaneous coronary intervention (PCI) success.
- The ability of coronary computed tomography angiography (CTA) to detect complex stenosis morphologies is not well-established.
Purpose of the Study:
- To evaluate CTA's accuracy in identifying complex coronary stenosis morphology prior to invasive coronary angiography (ICA) and PCI.
- To assess if CTA can predict PCI complexity based on lesion morphology.
Main Methods:
- CTA and ICA were performed on 85 patients; lesions >=70% stenotic were analyzed.
- Two blinded readers assessed CTA for complex morphology (Type C) using modified ACC criteria.
- Results were compared to ICA findings, and PCI duration/contrast use were analyzed.
Main Results:
- CTA identified 90% of significant stenoses and 79% of complex (Type C) lesions compared to ICA.
- Missed complex features included ostial involvement and long lesions; false positives involved major branches.
- Complex lesions identified by CTA correlated with longer PCI duration and increased contrast use.
Conclusions:
- CTA accurately predicts significant coronary stenosis and complex morphologies in vessels >=2mm.
- CTA findings of complex lesions correlate with increased procedural complexity and resource utilization during PCI.
Objectives:
This study sought to assess the ability of coronary computed tomography angiography (CTA) in identifying complex coronary stenosis morphology before invasive coronary angiography (ICA) and percutaneous coronary intervention (PCI).
Background:
Complexity of stenosis morphology affects PCI success. Whether CTA can detect the entire spectrum of recognized complex stenosis morphologies has not been investigated.
Methods:
All nonbypassed, nonstented, >or=2-mm-diameter native coronary arterial segments in 85 consecutive patients who underwent ICA
Results:
CTA detected 84 of 93 lesions (90%) causing >or=70% stenosis on ICA and correctly characterized 42 of 53 lesions (79%) found to concurrently show type C morphology on ICA. Type C features most frequently missed by CTA were ostial involvement (5 cases) and lesion length >20 mm (7 cases). Major branch involvement was the most frequent false-positive type C feature (12 cases). Mean PCI duration in patients with and without type C lesions on CTA were 42.4 +/- 24.7 min and 21.5 +/- 13.3 min (p = 0.009), respectively; mean total contrast used were 263 +/- 150 ml and 140 +/- 47 ml (p = 0.007), respectively.
Conclusions:
In vessels segments >or=2 mm in diameter, CTA can predict lesions likely to reach >or=70% stenosis on ICA and provide added value in discerning complex morphologies associated with these lesions. Presence of complex, severely obstructive lesions on CTA is associated with higher contrast use and greater procedure length during PCI.
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