Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The relationship between thyroid function and the renal response to parathyroid hormone.

J P Ashby, J N MacPherson, J A Strong

Clinical Endocrinology

|August 1, 1977

Summary

Thyroid status impacts kidney function. Hypothyroid patients showed a reduced renal response to parathyroid hormone (PTH), suggesting impaired cyclic AMP metabolism in the renal cortex.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats.

European journal of pain (London, England)·2015

Same author

Measurement of the inclusive jet cross-section in <i>pp</i> collisions at [Formula: see text] and comparison to the inclusive jet cross-section at [Formula: see text] using the ATLAS detector.

The European physical journal. C, Particles and fields·2015

Same author

Measurement of the charge asymmetry in top quark pair production in <i>pp</i> collisions at [Formula: see text] using the ATLAS detector.

The European physical journal. C, Particles and fields·2015

Same author

Search for lepton flavour violation in the <i>eμ</i> continuum with the ATLAS detector in [Formula: see text]<i>pp</i> collisions at the LHC.

The European physical journal. C, Particles and fields·2015

Same author

Measurement of [Formula: see text] production with a veto on additional central jet activity in <i>pp</i> collisions at [Formula: see text] TeV using the ATLAS detector.

The European physical journal. C, Particles and fields·2015

Same author

Measurement of the top quark mass with the template method in the [Formula: see text] channel using ATLAS data.

The European physical journal. C, Particles and fields·2015

Area of Science:

Endocrinology
Nephrology
Metabolism

Background:

Thyroid hormones play a crucial role in regulating various metabolic processes.
Renal adenosine 3', 5'-cyclic monophosphate (cyclic AMP) is a key second messenger involved in hormone signaling.
The interplay between thyroid status and parathyroid hormone (PTH)-mediated renal responses remains incompletely understood.

Purpose of the Study:

To investigate the effect of thyroid status (hypothyroid, hyperthyroid, euthyroid) on renal cyclic AMP metabolism.
To assess the renal response to parathyroid hormone (PTH) in different thyroid states.

Main Methods:

Measured plasma cyclic AMP concentrations after intravenous parathyroid hormone (PTH) administration.
Compared responses in hypothyroid, hyperthyroid, and euthyroid patient groups.

Related Experiment Videos

Correlated the cyclic AMP response magnitude with the free thyroxine index.

Main Results:

Parathyroid hormone (PTH) induced a rapid increase in plasma cyclic AMP in all groups.
The magnitude of the cyclic AMP response was similar in euthyroid and hyperthyroid individuals.
Hypothyroid patients exhibited a significantly reduced magnitude of plasma cyclic AMP response to PTH.

Conclusions:

The renal response to parathyroid hormone (PTH) is influenced by thyroid status.
Hypothyroidism may impair renal cyclic AMP turnover, diminishing the kidney's response to PTH.
Free thyroxine levels correlate positively with the renal cyclic AMP response to PTH.