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Compression strength and porosity of single-antibiotic cement vacuum-mixed with vancomycin
Hugh S Brock1, Patrick G Moodie, Kelly J Hendricks
1Department of Orthopedic Surgery, The University of Kansas Medical Center, Kansas City, USA.
Abstract:
We evaluated the ultimate compression strength (UCS), porosity, and fracture surface roughness of 2 commercially available single-antibiotic bone cements vacuum-mixed with additional amounts of vancomycin (2, 4, 6, and 8 g). At least 8 g could be added to Palacos R + 0.5 g gentamicin (UCS = 75.04 +/- 6.64 MPa) and no more than 6 g to Simplex P + 1 g tobramycin (UCS = 78.93 +/- 4.98 MPa) to maintain a UCS above the International Organization for Standardization minimum standard (70 MPa). Increasing vancomycin concentration correlated with a decrease in porosity but showed a trend towards greater fracture surface roughness.
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