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Updated: Jun 21, 2026

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Published on: May 30, 2025

Effects of cannabis on lung function: a population-based cohort study.

R J Hancox¹, R Poulton, M Ely

¹Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. bob.hancox@otago.ac.nz

The European Respiratory Journal

|August 15, 2009

Summary

Cannabis use may increase lung volumes and airway resistance, unlike tobacco, which is linked to reduced lung function. This study highlights distinct effects of cannabis versus tobacco on respiratory health.

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Area of Science:

Pulmonary Medicine
Respiratory Physiology
Cannabis Research

Background:

The impact of cannabis on lung function is not well understood and may differ from tobacco.
Previous research has yielded conflicting results regarding cannabis and lung health.

Purpose of the Study:

To compare the associations between cannabis use and tobacco use with lung function measures.
To investigate potential differences in respiratory effects between cannabis and tobacco.

Main Methods:

A population-based cohort study of 1,037 participants was conducted.
Cannabis and tobacco use were self-reported at multiple ages (18, 21, 26, 32 years).
Lung function was assessed using spirometry, plethysmography, and carbon monoxide transfer factor at age 32, with adjustments for concurrent substance use.

Main Results:

Cumulative cannabis use was associated with increased lung volumes (forced vital capacity, total lung capacity, functional residual capacity, residual volume) and higher airway resistance.
Cannabis use did not show associations with airflow obstruction (forced expiratory volume in 1 second, forced expiratory ratio) or impaired gas transfer (transfer factor).
Tobacco use was linked to decreased forced expiratory volume in 1 second, reduced forced expiratory ratio, lower transfer factor, and increased static lung volumes, but not airway resistance.

Conclusions:

Cannabis and tobacco exert different effects on lung function.
Cannabis use appears to be associated with lung hyperinflation and increased large-airways resistance.
Evidence for airflow obstruction or gas exchange impairment due to cannabis use was minimal.