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CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis

H Sato1, H R T Williams, P Spagnolo

  • 1Clinical Genomics Group Royal Brompton Hospital and NHLI, Imperial College, 1B Manresa Road, London SW3 6LR, UK. h.sato@imperial.ac.uk

The European Respiratory Journal
|August 15, 2009
PubMed
Summary

Genetic variations in Caspase recruitment domain (CARD)15 influence sarcoidosis severity and lung function. Specific CARD15 polymorphisms, particularly 2104T, are linked to advanced disease stages and reduced lung capacity, with a combined effect with CCR5 haplotype.

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