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Pressed for time: the circadian clock and hypertension
R Daniel Rudic1, David J Fulton
1Department of Pharmacology and Toxicology, 1120 15th St., Medical College of Georgia, Augusta, GA 30912, USA. rrudic@mcg.edu
Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 15, 2009
Summary
The circadian clock significantly influences blood pressure regulation. Disruptions in this internal clock contribute to the development and progression of hypertension and related vascular diseases.
Area of Science:
- Cardiovascular Physiology
- Chronobiology
- Molecular Medicine
Background:
- Hypertension is a primary risk factor for cardiovascular disease, end-organ damage, and mortality.
- Elevated blood pressure often develops asymptomatically over time, highlighting the need to understand its underlying mechanisms.
Purpose of the Study:
- To explore recent findings on how the circadian clock regulates blood pressure.
- To elucidate the role of circadian clock mechanisms in the development of hypertension and vascular disease.
Main Methods:
- Review of recent human and animal studies.
- Analysis of molecular components of the circadian clock.
- Examination of relationships between circadian clock, activity, metabolism, and vascular function.
Main Results:
- The circadian clock plays a crucial role in regulating blood pressure.
- Molecular clock components are linked to locomotor activity, metabolic control, fluid balance, and vascular resistance.
- Dysregulation of circadian mechanisms contributes to hypertension development.
Conclusions:
- Novel insights reveal the circadian clock's significant contribution to blood pressure homeostasis.
- Understanding these clock-controlled mechanisms offers new avenues for hypertension research and treatment.
- Circadian clock dysregulation is a key factor in the pathogenesis of hypertension and vascular disease.
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