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Updated: Jun 21, 2026

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

Published on: August 15, 2018

Lung function in developing lambs: is it affected by preterm birth?

Robert De Matteo¹, Ken Snibson, Bruce Thompson

¹Department of Anatomy and Developmental Biology, Bldg. 76, Monash Univ., Melbourne, Victoria 3800, Australia. Robert.dematteo@med.monash.edu.au

Journal of Applied Physiology (Bethesda, Md. : 1985)

|August 15, 2009

Summary

This summary is machine-generated.

Preterm birth in lambs did not impact airway resistance, responsiveness, or gas mixing. However, sex differences were observed in airway responsiveness and conducting airway gas mixing, potentially explaining human lung function variations.

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Last Updated: Jun 21, 2026

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

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Published on: August 15, 2018

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

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Published on: December 22, 2023

Area of Science:

Neonatal Physiology
Respiratory Medicine
Comparative Physiology

Background:

Preterm birth can impair lung function, but isolating its effects from medical interventions like mechanical ventilation is challenging.
Understanding the isolated impact of preterm birth on developing airways is crucial for pediatric respiratory health.

Purpose of the Study:

To investigate the independent effects of preterm birth on airway resistance, airway reactivity, and ventilatory heterogeneity in a lamb model.
To assess intrapulmonary gas mixing using multiple breath nitrogen washout (MBW).

Main Methods:

Preterm birth was induced in sheep 12 days before term; controls were born at term.
Lung function was assessed at 8 weeks postterm.
Airway resistance and carbachol reactivity were measured; ventilatory heterogeneity (S(cond), S(acin)) was assessed via MBW.

Main Results:

No significant differences in baseline airway resistance or carbachol responsiveness were found between preterm and term lambs.
Ventilatory heterogeneity (S(cond) and S(acin)) did not differ between preterm and term groups.
Females exhibited greater airway responsiveness to carbachol than males; males had poorer gas mixing in conducting airways (higher S(cond)).

Conclusions:

Preterm birth per se, in this lamb model, does not adversely affect baseline airway resistance, responsiveness, or ventilatory heterogeneity.
Observed sex-based differences in airway function and gas mixing may offer insights into human sex disparities in lung function.