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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Functional Classification of Joints01:09

Functional Classification of Joints

Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An immobile...
Overview of the Axial Skeleton01:09

Overview of the Axial Skeleton

The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the adult...
Bones of the Upper Limb: Radius01:09

Bones of the Upper Limb: Radius

The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a short...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

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Related Experiment Video

Updated: Jun 21, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Axial gouty arthropathy.

Lesley Ann Saketkoo1, Hugh J Robertson, Herbert R Dyer

  • 1Section of Rheumatology, Department of Internal Medicine, Louisiana State University Health Sciences Center, 820 Napoleon Avenue, Suite 890, New Orleans, LA 70115, USA. saketkoo.md@gmail.com

The American Journal of the Medical Sciences
|August 15, 2009
PubMed
Summary
This summary is machine-generated.

Spinal gout, though uncommon, causes cord compression and myelopathy. Early diagnosis and treatment, including uric acid-lowering therapy, can reverse symptoms and prevent further damage.

Related Experiment Videos

Last Updated: Jun 21, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Spinal Gout
  • Rheumatology
  • Neurology

Background:

  • Spinal gout is an underrecognized cause of myelopathy and cord compression.
  • Bony destruction from gout typically appears years after initial diagnosis.
  • Hypertension, diabetes, and atherosclerosis are linked to gout and hyperuricemia.

Purpose of the Study:

  • To highlight spinal gout as a significant differential diagnosis for back pain.
  • To review the diagnostic and therapeutic approaches for spinal gout.
  • To reinforce the association between gout, metabolic syndrome, and cardiovascular disease.

Main Methods:

  • Literature review and case collation.
  • Analysis of radiological findings, including MRI signal enhancement.
  • Evaluation of treatment outcomes with surgical and medical interventions.

Main Results:

  • 52 new cases were added to 73 previously reported cases of spinal gout.
  • Magnetic resonance imaging (MRI) signal enhancement aids in diagnosing gouty involvement.
  • Timely intervention can reverse cord compression sequelae and radiculopathy.

Conclusions:

  • Spinal gout should be considered in patients with back pain and risk factors for gout.
  • Effective management involves uric acid-lowering therapy and potentially surgical decompression.
  • Further investigation into gout as a contributor to chronic back pain is warranted.