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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Repeatability of pattern electroretinogram measurements using a new paradigm optimized for glaucoma detection.

Christopher Bowd1, Ali Tafreshi, Gianmarco Vizzeri

  • 1Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA 92037-0946, USA. cbowd@glaucoma.ucsd.edu

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Summary

The new PERGLA instrument shows good repeatability for pattern electroretinogram (PERG) measurements in both healthy and patient eyes. This suggests the PERG technique is promising for monitoring changes over time.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Instrumentation

Background:

  • Pattern electroretinogram (PERG) is a valuable tool for assessing retinal function.
  • Evaluating the repeatability of new diagnostic instruments is crucial for clinical adoption.
  • The PERGLA is a novel instrument designed for PERG measurements.

Purpose of the Study:

  • To assess the within-trial and between-trial repeatability of PERG measurements using the PERGLA instrument.
  • To compare the repeatability of PERG amplitude and phase in healthy and patient eyes.

Main Methods:

  • PERG recordings were obtained from 70 eyes of 35 healthy individuals and 90 eyes of 45 glaucoma patients.
  • The PERGLA instrument was used to record PERG from both eyes simultaneously, with electrodes removed and reattached between trials.
  • Repeatability was assessed by calculating coefficients of variability (CVs) and intraclass correlation coefficients (ICCs), and using Bland-Altman plots.

Main Results:

  • For healthy eyes, PERG amplitude CVs were 11.5% (within-trial) and 9.9% (between-trial), with ICCs of 0.91 and 0.85, respectively.
  • For patient eyes, amplitude CVs were 12.2% (within-trial) and 11.2% (between-trial), with ICCs of 0.92 and 0.89, respectively.
  • Phase CVs and ICCs demonstrated good repeatability for both healthy and patient eyes, with results similar between within-trial and between-trial conditions.

Conclusions:

  • The PERGLA instrument demonstrates good repeatability for PERG measurements.
  • Repeatability is consistent for both within-trial and between-trial conditions.
  • The PERG technique using the PERGLA shows promise for monitoring functional changes in ocular conditions over time.