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Related Concept Videos

Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: Jun 21, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

From small reads do mighty genomes grow.

Nicholas J Croucher1

  • 1Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. microbes@sanger.ac.uk

Nature Reviews. Microbiology
|August 15, 2009
PubMed
Summary
This summary is machine-generated.

Next-generation sequencing technologies were used to assemble draft genomes for two pseudomonad species. This advancement aids in understanding bacterial genomics and evolution.

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Large-Scale Screens of Metagenomic Libraries
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Large-Scale Screens of Metagenomic Libraries

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Last Updated: Jun 21, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
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Published on: March 15, 2019

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

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Large-Scale Screens of Metagenomic Libraries

Published on: May 28, 2007

Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Pseudomonad species are important in various environments.
  • Genomic information is crucial for understanding bacterial biology.

Purpose of the Study:

  • To describe the application of next-generation sequencing (NGS) for genome assembly.
  • To present draft genome sequences for two specific pseudomonad species.

Main Methods:

  • Utilized next-generation sequencing platforms.
  • Employed bioinformatics tools for genome assembly and analysis.

Main Results:

  • Successfully generated draft genome sequences for two pseudomonad species.
  • The study highlights the efficiency of NGS in bacterial genomics.

Conclusions:

  • NGS technologies are effective for rapid genome assembly.
  • The generated draft genomes provide valuable resources for future pseudomonad research.