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Updated: Jun 21, 2026

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
Published on: April 28, 2016
The precursors of memory: models and controversies
Rafi Ahmed1, Michael J Bevan, Steven L Reiner
1Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, USA. rahmed@emory.edu
Abstract:
The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.
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