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High hydrostatic pressure for development of vaccines
Adrienne E H Shearer1, Kalmia E Kniel
1Department of Animal and Food Sciences, University of Delaware, 044 Townsend Hall, 531 South College Avenue, Newark, Delaware 19716-2150, USA. ashearer@udel.edu
Journal of Food Protection
|August 18, 2009
Summary
High hydrostatic pressure (HHP) shows promise for developing new vaccines against foodborne pathogens. This method may offer a safer and more consistent alternative to traditional vaccine production techniques.
Area of Science:
- Food Science
- Microbiology
- Immunology
- Biotechnology
Background:
- Disease management in the food industry relies on hygiene, antimicrobials, and vaccines.
- Limited vaccine availability for foodborne pathogens and increasing antimicrobial resistance necessitate new vaccine development.
- Current vaccine production methods can be hazardous, inconsistent, or allergenic.
Purpose of the Study:
- To explore the potential of high hydrostatic pressure (HHP) for developing novel vaccines.
- To investigate the efficacy of HHP in inactivating foodborne pathogens while retaining immunogenicity.
- To assess HHP's application in vaccine production for animal health and food safety.
Main Methods:
- Review of studies on the effects of HHP on various foodborne pathogens, including viruses, a protozoan parasite, and bacteria.
- Evaluation of HHP's impact on pathogen infectivity and immunogenicity.
- Analysis of HHP's potential as a vaccine production technology.
Main Results:
- HHP effectively inactivates a range of foodborne pathogenic microorganisms.
- Some microorganisms treated with HHP retain their immunogenic properties.
- Studies demonstrate HHP's effect on the infectivity and immunogenicity of diverse pathogens.
Conclusions:
- High hydrostatic pressure (HHP) presents a viable method for developing new vaccines against foodborne pathogens.
- HHP offers a potentially safer and more consistent alternative to conventional vaccine production.
- Further research into HHP-based vaccine development is warranted for animal health and food industry applications.
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