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Updated: Jun 21, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Systemic and non-systemic vasculitis affecting the peripheral nerves.

J Finsterer1

  • 1Krankenanstalt Rudolfstiftung, Vienna, Austria, Europe. fipaps@yahoo.de

Acta Neurologica Belgica
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Peripheral nerve vasculitis presents as neuropathy, often asymmetric. Diagnosis requires nerve biopsy, and treatment involves corticosteroids, cyclophosphamide, or other immunosuppressants.

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Area of Science:

  • Neurology
  • Rheumatology
  • Pathology

Background:

  • Vasculitis impacting peripheral nerves typically causes subacute, progressive, asymmetric sensorimotor polyneuropathy or mononeuritis multiplex.
  • It can manifest as isolated or systemic disease, involving other organs.

Purpose of the Study:

  • To outline the clinical presentation, classification, diagnostic approaches, and therapeutic strategies for vasculitic neuropathy.

Main Methods:

  • Review of clinical manifestations, diagnostic tools including nerve conduction studies and nerve biopsy, and treatment options for vasculitic neuropathy.
  • Classification of systemic vasculitis involving peripheral nerves into primary and secondary categories.

Main Results:

  • Vasculitic neuropathy presents with diverse neurological deficits.
  • Nerve biopsy is crucial for diagnosis, though sensitivity is limited (~60%).
  • Treatment strategies vary based on etiology, often involving corticosteroids and immunosuppressants.

Conclusions:

  • Early diagnosis and appropriate treatment are essential for managing vasculitic neuropathy.
  • Treatment regimens are tailored to the specific type of vasculitis and may include corticosteroids, cyclophosphamide, and other immunomodulatory agents.