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Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients

V Danzig1, B Míková, P Kuchynka

  • 1Second Department of Medicine, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic.

Physiological Research
|August 18, 2009
PubMed

Insights

Coronary artery disease (CAD) patients exhibit elevated levels of novel cardiovascular risk markers, including high-sensitive C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). Exercise significantly increases MMP-9 and B-type natriuretic peptide (BNP) in both patients and healthy individuals.

Area of Science:

  • Cardiology
  • Biochemistry
  • Exercise Physiology

Background:

  • Traditional risk factors inadequately explain coronary artery disease (CAD) pathogenesis.
  • Novel mechanisms and biomarkers are crucial for understanding CAD.
  • Physical exercise may modulate key cardiovascular risk markers.

Purpose of the Study:

  • To investigate the response of novel cardiovascular markers to physical exercise in CAD patients.
  • To compare marker levels at rest and post-exercise between CAD patients and healthy controls.
  • To identify exercise-induced changes in biomarkers related to cardiovascular risk and cardiac overload.

Main Methods:

  • Serum levels of hs-CRP, MMP-2, MMP-9, AOPP, sRAGE, PAPP-A, E-selectin, VEGF, and BNP were measured.
  • Measurements were taken from 21 CAD patients and 22 healthy controls at rest and after a maximal exercise stress test.
  • Comparative analysis was performed between groups and conditions.

Main Results:

  • At rest, CAD patients showed significantly higher hs-CRP, AOPP, MMP-9, and BNP compared to controls.
  • P-selectin was lower in CAD patients, with a trend towards lower sRAGE.
  • MMP-9 and BNP levels significantly increased post-exercise in both groups.

Conclusions:

  • CAD patients present elevated levels of novel markers: hs-CRP, AOPP, MMP-9, and BNP.
  • These markers are associated with cardiovascular risk and left ventricular overload.
  • MMP-9 and BNP exhibit significant exercise-induced increases in both healthy individuals and CAD patients.

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