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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

Updated: Jun 21, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Published on: February 3, 2023

Thyroid tumors: novel insights from proteomic studies.

Giuseppe Damante1, Andrea Scaloni, Gianluca Tell

  • 1Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 1, 33100 Udine, Italy. giuseppe.damante@uniud.it

Expert Review of Proteomics
|August 18, 2009
PubMed
Summary

Proteomics advances cancer research by identifying biomarkers for early diagnosis and treatment prediction. This review highlights key proteomic findings in thyroid follicular cell tumors, aiding molecular characterization.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Genomics and proteomics are vital for cancer molecular characterization, improving diagnosis and treatment prediction.
  • Proteomic techniques are crucial for discovering biomarkers for early tumor diagnosis and prognosis.
  • Molecular characterization of thyroid tumors has significantly benefited from proteomic approaches.

Purpose of the Study:

  • To review the most relevant proteomic findings in thyroid follicular cell tumors.
  • To summarize the application of various proteomic approaches in understanding thyroid cancer.
  • To provide an overview of the current state of proteomics in thyroid tumor research.

Main Methods:

  • Review of published proteomic studies on thyroid tumors.
  • Analysis of data from proteomic studies on model systems, tumor specimens, and serum.
  • Synthesis of results from diverse proteomic techniques applied to thyroid cancer.

Main Results:

  • Proteomic studies have enhanced the molecular characterization of thyroid tumors.
  • Key biomarkers for early diagnosis and prognosis have been identified through proteomics.
  • Understanding of the molecular basis of thyroid cancer has been advanced by proteomic investigations.

Conclusions:

  • Proteomics offers powerful tools for the molecular characterization of thyroid tumors.
  • Proteomic biomarkers hold significant potential for improving thyroid cancer diagnosis and patient outcomes.
  • Continued proteomic research is essential for advancing thyroid cancer understanding and management.