Related Experiment Video
Updated: Jun 21, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Life-threatening systemic toxicity and airway compromise from a common European adder bite to the tongue
L C G Hoegberg1, C L Jessen, K Lambertsen
1Department of Anaesthesia and Intensive Care Medicine, The Danish Poison Information Centre, Bispebjerg University Hospital, Bispebjerg Bakke 23, 60.1, Copenhagen, Denmark. LHOE0021@bbh.regionh.dk
Abstract:
A 24-year-old man was bit on the tongue by a European common adder. Within 15 min following envenomation, he experienced tongue swelling, hypotension and impaired consciousness. Antihistamine, corticosteroid and crystalloids were administered. Within 105 min of envenomation, increasing oral, pharyngeal and facial oedema compromised the airway, leading to respiratory failure, concomitant with circulatory failure related to hypoxaemia and systemic toxic effects. Acute tracheotomy secured the airway, and two doses of antivenom successfully treated the systemic, toxic effects. The reaction was severe due to rapid and suspected high-dose uptake of venom, underlining the need for early advanced symptomatic treatment with airway control and early and eventually repeated dosing of antivenom.
Related Concept Videos
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Drug Toxicity: Overview
Inhalation Anthrax
Allergic Reactions
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Diphtheria

