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Accelerated photo-induced hydrophilicity promotes osseointegration: an animal study
Ryo Jimbo1, Daisuke Ono, Yuko Hirakawa
1Division of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan.
Background:
In the previous in vitro study, fluoride-modified, anodized porous titanium was proven to have enhanced its photo-induced hydrophilicity, which induced the hyperactivation of initial cell response.
Purpose:
The purpose of the present study was to investigate in vivo bone apposition during the early stages of osseointegration in rabbit tibiae.
Materials And Methods:
Anodized porous titanium implants (TiU, TiUnite®, Nobel Biocare AB, Göteborg, Sweden) were modified with 0.175 wt% ammonium hydrogen fluoride solution (NH(4) F-HF(2) ). Twenty-four hours prior to the experiments, the surface-modified implants were ultraviolet-irradiated (modTiU). Blinded and unpackaged TiU implants were used as controls. Thereafter, the implants were placed in the rabbit tibial metaphyses and histomorphometrically analyzed at 2 and 6 weeks after insertion.
Results:
ModTiU demonstrated a significantly greater degree of bone-to-metal contact than TiU after 2 and 6 weeks of healing.
Conclusion:
The results proved that the enhanced photo-induced hydrophilicity of the NH(4) F-HF(2) -modified anodized implants promoted bone apposition during the early stages of osseointegration.
