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Updated: Jun 21, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
Instituting a thawed plasma procedure: it just makes sense and saves cents
Gay Wehrli1, Nancy E Taylor, Annette L Haines
1Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908-0286, USA. GWMD@virginia.edu
Background:
The objectives of this time-series study were to elucidate the impact of a thawed plasma standard operating procedure (TP SOP) on plasma wastage and on cost savings.
Study Design And Methods:
This study compared plasma wastage for 1 year before versus 1 year after implementation of a TP SOP.
Results:
The plasma wastage and discard declined 79.7 and 64.9%, respectively, with a cost savings of $15,654.79 during the 1 year after implementation of the TP SOP. The risk that a unit of plasma would be wasted decreased 86.2% from Year 1 to Year 2 and the risk that a unit of plasma would be discarded decreased 76.3% from Year 1 to Year 2.
Conclusion:
Our study showed the positive, sustained, impact of implementing a TP SOP. Twelve months after introducing the SOP our Blood Bank and Transfusion Medicine Services' plasma wastage and discard were dramatically reduced, saving thousands of dollars. Initiating a TP SOP just makes sense; it is easy to implement, conserves plasma, and saves cents.

