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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Involvement of mitochondrial permeability transition in hepatitis B virus replication

Chang Tan1, Hua Guo, Maofa Zheng

  • 1Department of Biochemistry, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, China.

Virus Research
|August 18, 2009
PubMed
Summary

Hepatitis B virus (HBV) HBx protein induces mitochondrial permeability transition (MPT), a process crucial for viral replication. Inhibiting MPT via targeting Cyclophilin D suppressed HBV DNA replication, suggesting MPT as a therapeutic target.

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