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Related Experiment Video

Updated: Jun 21, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
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Motor cortex stimulation for ALS: a double blind placebo-controlled study.

Vincenzo Di Lazzaro1, Fabio Pilato, Paolo Profice

  • 1Institute of Neurology, Università Cattolica, 00168 Rome, Italy. vdilazzaro@rm.unicatt.it

Neuroscience Letters
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Continuous theta burst stimulation (cTBS) did not significantly slow disease progression in amyotrophic lateral sclerosis (ALS) patients over one year. This repetitive transcranial magnetic stimulation (rTMS) approach was safe but did not demonstrate efficacy in this trial.

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Trials

Background:

  • Preliminary data suggested repetitive transcranial magnetic stimulation (rTMS) might slow amyotrophic lateral sclerosis (ALS) progression.
  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options.

Purpose of the Study:

  • To test if continuous theta burst stimulation (cTBS), a form of rTMS, repeated monthly for one year, could affect ALS progression.
  • To evaluate the efficacy of cTBS in slowing the decline of functional status in ALS patients.

Main Methods:

  • A double-blind, placebo-controlled trial involving twenty ALS patients.
  • Patients received either real or placebo cTBS of the motor cortex for five consecutive days monthly for one year.
  • The primary outcome measure was the rate of decline assessed by the revised ALS functional rating scale (ALSFRS-R).

Main Results:

  • Treatment with cTBS was well tolerated by all patients.
  • No significant difference in ALSFRS-R score deterioration was observed between the real cTBS and placebo groups.
  • Mean ALSFRS-R scores declined from baseline to 12 months in both groups, with similar rates of progression.

Conclusions:

  • Continuous theta burst stimulation (cTBS) is a safe intervention for ALS patients.
  • The study did not find evidence that monthly cTBS over one year slows ALS progression.
  • Further large-scale randomized trials investigating cTBS for ALS appear unjustified, particularly in advanced stages.