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Association of the herpes simplex virus major tegument structural protein VP22 with chromatin

Kristin Ingvarsdottir1, John A Blaho

  • 1Virology Research Division, Medical Diagnostic Laboratories, LLC, 2439 Kuser Road, Hamilton, NJ 08690-3303, USA.

Biochimica Et Biophysica Acta
|August 18, 2009
PubMed

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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