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Related Concept Videos

Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Colloids and Suspensions01:17

Colloids and Suspensions

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Published on: February 19, 2016

Soft matter dispersions with ordered inner structures, stabilized by ethoxylated phytosterols.

Dima Libster1, Abraham Aserin, Doron Yariv

  • 1Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Colloids and Surfaces. B, Biointerfaces
|August 18, 2009
PubMed
Summary

This study explores ethoxylated phytosterol (PhEO) as a stabilizer for liquid crystalline dispersions, creating novel hexosomes. PhEO effectively stabilizes these soft particles for drug delivery, influencing their structure and release profiles.

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Area of Science:

  • Materials Science
  • Colloid and Surface Science
  • Biomedical Engineering

Background:

  • Liquid crystalline dispersions (LCDs) are typically stabilized by Pluronic copolymers.
  • Non-polymeric surfactants like ethoxylated phytosterol (PhEO) are less common for stabilizing ordered liquid crystalline phases.
  • Understanding stabilizer effects is crucial for controlling particle properties and applications.

Purpose of the Study:

  • To investigate the formation and characterization of liquid crystalline dispersions (hexosomes) using ethoxylated phytosterol (PhEO) as a non-polymeric stabilizer.
  • To explore the influence of PhEO concentration and processing conditions on hexosome properties (internal structure, size, stability).
  • To evaluate the potential of PhEO-stabilized hexosomes as delivery vehicles for the peptide desmopressin.

Main Methods:

  • Formation and characterization of hexagonal liquid crystalline dispersions (hexosomes) using GMO/tricaprylin/water.
  • Utilized ethoxylated phytosterol (PhEO) with 30 oxyethylene units as a non-ionic, non-polymeric surfactant.
  • Physical stability assessed using the LUMiFuge technique.
  • Phase behavior analysis of the bulk H(II) mesophase system.
  • Drug release studies using the therapeutic peptide desmopressin.

Main Results:

  • PhEO effectively stabilized hexosomes within a narrow concentration range (0.1-0.2 wt%), coexisting with vesicles and disordered particles.
  • PhEO induced phase transitions (H(II) to cubic and lamellar phases) and reduced domain size.
  • Hydration of PhEO's oxyethylene groups and decreased hydrogen bonding of monoolein were key to observed behavior.
  • PhEO-stabilized hexosomes exhibited sustained release of desmopressin over 10 hours, followed by increased permeation.

Conclusions:

  • Ethoxylated phytosterol (PhEO) is a viable non-polymeric stabilizer for creating ordered liquid crystalline dispersions (hexosomes).
  • PhEO concentration critically controls hexosome structure, stability, and phase behavior.
  • PhEO-stabilized hexosomes show promise as drug delivery vehicles, demonstrating controlled release of desmopressin.