Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retrograde Nailing of an Unstable Distal-Third Femoral Shaft Fracture Using Pure Indirect Reduction: A Case Report in Osteoporotic Bone.

Journal of orthopaedic case reports·2026
Same author

When the Nerve Lies Between the Fragments: A Mid-Shaft Humeral Fracture Mimicking a Holstein-Lewis Injury.

Journal of orthopaedic case reports·2026
Same author

Application of 16S rRNA gene amplicon sequencing in the investigation of novel ovine skin lesions in Norway.

Frontiers in veterinary science·2026
Same author

Assessment of Lumbar Foraminal Stenosis: Diagnostic Value and Clinical Correlation: A Systematic Review.

Journal of orthopaedic case reports·2026
Same author

Planned Fibular Osteotomy as a Method of Biological Dynamization in the Staged Damage-Control Management of a Fraser Type I Floating Knee.

Journal of orthopaedic case reports·2026
Same author

Atypical Transverse Midshaft Humerus Fracture in an Octogenarian: Surgical Nuances and Functional Outcome Following Locked Intramedullary Nailing.

Journal of orthopaedic case reports·2025

Related Experiment Video

Updated: Jun 21, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Constrained non-rigid registration for use in image-guided adaptive radiotherapy.

W H Greene1, S Chelikani, K Purushothaman

  • 1Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA. william.h.greene@aya.yale.edu

Medical Image Analysis
|August 18, 2009
PubMed
Summary

A new constrained non-rigid registration (CNRR) algorithm improves prostate cancer radiotherapy by accurately aligning organs and bones. This method enhances radiation delivery to the prostate while sparing surrounding tissues.

More Related Videos

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Related Experiment Videos

Last Updated: Jun 21, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Image-guided therapy

Background:

  • Accurate patient positioning and organ alignment are crucial for effective radiotherapy.
  • Inter-day variations in patient anatomy, including bone motion and organ deformation, pose challenges in adaptive radiotherapy.

Purpose of the Study:

  • To present a constrained non-rigid registration (CNRR) algorithm for prostate image-guided adaptive radiotherapy.
  • To evaluate the performance of CNRR in aligning critical organs and bones for dose adaptation.

Main Methods:

  • Developed a CNRR algorithm combining global rigid and local non-rigid Free Form Deformation (FFD) transformations.
  • Utilized control points for non-rigidly constraining transformations to the prostate, rectum, and bladder.
  • Applied rigid constraints to pelvic and femur bones to improve registration accuracy.
  • Tested the algorithm with 3D conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) datasets.

Main Results:

  • CNRR significantly outperformed rigid and non-rigid registration methods in aligning bones and organs.
  • Tested CNRR with various anatomical constraint combinations, showing consistent improvements.
  • Adapted dose plans using CNRR results reduced radiation to the rectum and bladder.
  • Maintained or increased radiation dose to the prostate in adapted plans.

Conclusions:

  • The CNRR algorithm provides a robust framework for accurate image registration in prostate radiotherapy.
  • CNRR enables effective dose adaptation by accounting for patient positioning errors and anatomical variations.
  • This approach enhances treatment efficacy and safety by optimizing radiation delivery.