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A reverse-phase liquid chromatography/mass spectrometry method for the analysis of high-molecular-weight

Scott J Harrison1, Karl Fraser, Geoffrey A Lane

  • 1Grasslands Research Centre, Palmerston North, New Zealand.

Analytical Biochemistry
|August 18, 2009
PubMed

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Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...