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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

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Related Experiment Video

Updated: Jun 21, 2026

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
08:54

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Published on: May 20, 2020

Metastasis mechanisms.

Thomas R Geiger1, Daniel S Peeper

  • 1Division of Molecular Genetics, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

Biochimica Et Biophysica Acta
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Metastasis, the spread of cancer, involves a cascade of steps including EMT and angiogenesis. Understanding these processes and new findings like premetastatic niches offers novel therapeutic targets.

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Related Experiment Videos

Last Updated: Jun 21, 2026

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
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Primary Tumor and MEF Cell Isolation to Study Lung Metastasis
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Primary Tumor and MEF Cell Isolation to Study Lung Metastasis

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Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Metastasis, the spread of malignant cells, is the primary cause of cancer-related mortality.
  • The metastatic cascade outlines the sequential steps involved in cancer spread.
  • Understanding metastasis is crucial for developing effective cancer treatments.

Purpose of the Study:

  • To comprehensively review the molecular and cellular mechanisms of the metastatic cascade.
  • To incorporate recent findings that challenge the classical view of metastasis.
  • To identify potential novel therapeutic targets for intervention.

Main Methods:

  • Literature review and synthesis of existing research on cancer metastasis.
  • Detailed description of molecular and cellular processes involved in metastasis.
  • Integration of recent discoveries, including premetastatic niche formation and cancer stem cells.

Main Results:

  • Detailed elucidation of key steps: Epithelial-Mesenchymal Transition (EMT), invasion, anoikis, angiogenesis, vascular transport, and secondary tumor outgrowth.
  • Discussion of emerging concepts such as the premetastatic niche, cancer stem cell properties, tumor stroma interactions, and paracrine signaling.
  • Highlighting how these processes contribute to the overall metastatic cascade.

Conclusions:

  • A deeper understanding of the molecular mechanisms of metastasis is essential.
  • Recent findings expand and challenge the traditional metastatic cascade model.
  • Elucidating these processes can lead to the identification of novel therapeutic targets for cancer treatment.