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Related Experiment Video

Updated: Jun 20, 2026

Zebrafish Model of Neuroblastoma Metastasis

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

Increased tissue factor expression and poor nephroblastoma prognosis.

Elinês O Maciel¹, Gustavo F Carvalhal, Vinícius D da Silva

¹Department of Pediatric Surgery, Pontifícia Universidade Católica, Porto Alegre, Brazil.

The Journal of Urology

|August 18, 2009

Summary

Tissue factor expression is common in Wilms tumors and linked to higher recurrence and mortality. This finding highlights tissue factor as a potential prognostic marker for improved patient outcomes.

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Last Updated: Jun 20, 2026

Zebrafish Model of Neuroblastoma Metastasis

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

Area of Science:

Oncology
Hematology
Pathology

Background:

Malignant cell growth interacts with the coagulation pathway.
Tissue factor (TF) initiates the extrinsic coagulation pathway and is expressed in solid tumors, correlating with angiogenesis.

Purpose of the Study:

To detect tissue factor expression in Wilms tumors using immunohistochemistry.
To correlate tissue factor expression with clinical outcomes, including tumor recurrence and cancer-specific survival.

Main Methods:

Tissue factor expression was assessed via immunohistochemistry in 41 formalin-fixed, paraffin-embedded Wilms tumor samples.
Correlation analysis was performed between tissue factor detection and tumor recurrence/cancer-specific survival.

Main Results:

Tissue factor was detected in 88.3% of analyzed Wilms tumors.
Increased tissue factor expression correlated significantly with tumor recurrence (p=0.01) and mortality (p=0.02).
Tissue factor emerged as a key independent risk factor for recurrence and mortality in multivariate analysis.

Conclusions:

Tissue factor shows promise as a prognostic factor for Wilms tumor.
Further research is needed to elucidate TF's role in cancer progression and its potential as a therapeutic target.