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Related Concept Videos

Channel Rhodopsins01:11

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...

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Related Experiment Video

Updated: Jun 20, 2026

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

CCR3: Shedding new light on a dark problem?

A Brett Mason1, Josephine Hoh

  • 1Yale University School of Medicine, New Haven, CT 06510, USA. alan.mason@yale.edu

Journal of Molecular Cell Biology
|August 18, 2009
PubMed
Summary

Chemokine receptor CCR3 shows promise as an early diagnostic marker and therapeutic target for age-related macular degeneration. This finding could lead to more effective treatments for choroidal neovascularization, a key aspect of the disease.

Area of Science:

  • Ophthalmology
  • Immunology
  • Molecular Biology

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Choroidal neovascularization (CNV) is a critical pathological feature of wet AMD.
  • Current treatments for AMD have limitations.

Purpose of the Study:

  • To investigate the role of chemokine receptor CCR3 in the development of choroidal neovascularization.
  • To identify potential early diagnostic markers for AMD.
  • To explore CCR3 as a therapeutic target for AMD.

Main Methods:

  • The study analyzed the expression and function of CCR3 in models of choroidal neovascularization.
  • Investigated the correlation between CCR3 levels and AMD progression.

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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Related Experiment Videos

Last Updated: Jun 20, 2026

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Main Results:

  • Evidence suggests CCR3 is an early marker for choroidal neovascularization development.
  • CCR3 plays a significant role in the pathogenesis of CNV.
  • CCR3 presents a potential therapeutic target for AMD.

Conclusions:

  • CCR3 is a promising early diagnostic biomarker for AMD.
  • Targeting CCR3 may offer a novel therapeutic strategy for AMD and its associated CNV.