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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

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Related Experiment Video

Updated: Jun 20, 2026

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

ACROSTUDY: the first 5 years.

Peter J Trainer¹

¹Department of Endocrinology, Christie Hospital, Manchester, UK. peter.trainer@manchester.ac.uk

European Journal of Endocrinology

|August 18, 2009

Summary

The ACROSTUDY registry shows pegvisomant therapy is generally safe, but less than 70% of patients achieved normal IGF1 levels. This may be due to suboptimal pegvisomant dosing strategies.

Area of Science:

Endocrinology
Pharmacovigilance
Acromegaly Treatment

Background:

Pegvisomant is a growth hormone receptor antagonist used to treat acromegaly.
Observational studies are crucial for assessing long-term safety and efficacy in real-world settings.

Purpose of the Study:

To evaluate the safety and efficacy of pegvisomant therapy in a large patient cohort.
To identify factors influencing treatment outcomes and adverse events.

Main Methods:

Observational registry (ACROSTUDY) collecting data from 792 patients treated with pegvisomant.
Analysis of patient demographics, treatment duration, dosing, IGF1 normalization, adverse events, and tumor size changes via MRI.

Main Results:

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Mean follow-up of 1.66 years; 2625 patient-years of pegvisomant treatment.

IGF1 normalization achieved in <70% of patients, with many on low doses (≤20 mg).

56 serious adverse events reported (13 related to pegvisomant); common AEs include liver function abnormalities and injection site reactions. Tumor size changes varied, with decreases in 31 patients and increases in 22.

Conclusions:

Pegvisomant demonstrates a generally reassuring safety profile.
Suboptimal IGF1 normalization rates suggest potential issues with dose titration and require further investigation.