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Assessing the Effects of Music Listening on Psychobiological Stress in Daily Life
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The German ACROSTUDY: past and present.

M Buchfelder1, S Schlaffer, M Droste

  • 1Department of Neurosurgery, University of Erlangen-Nürnberg, Germany. michael.buchfelder@uk-erlangen.de

European Journal of Endocrinology
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Pegvisomant (Somavert) effectively normalizes IGF1 levels in most acromegaly patients. Long-term safety data show rare tumor progression and manageable liver function abnormalities.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Clinical Research

Background:

  • Acromegaly is a chronic condition caused by excess growth hormone.
  • Pharmacotherapy with pegvisomant offers a treatment option for acromegaly.
  • Limited initial clinical experience necessitated further safety and efficacy evaluation.

Purpose of the Study:

  • To assess the long-term safety and efficacy of pegvisomant in acromegaly patients.
  • To collect real-world data on pegvisomant treatment outcomes.
  • To contribute to the global ACROSTUDY database.

Main Methods:

  • An observational study in Germany involving 371 acromegaly patients treated with pegvisomant.
  • Efficacy monitored via IGF1 levels and patient-reported symptoms.
  • Safety assessed through liver function tests, glucose levels, HbA1c, and MRI for tumor size.

Main Results:

  • IGF1 normalization achieved in 71.3% of patients by 24 months.
  • Treatment discontinuation occurred in 10.9% of patients due to adverse events.
  • Elevated transaminases were observed in 20 patients, often normalizing with or without dose adjustment.
  • Tumor progression was rare, not exceeding expected rates.

Conclusions:

  • Pegvisomant demonstrates sustained efficacy in normalizing IGF1 levels in acromegaly patients.
  • Long-term safety profile is encouraging, with manageable adverse events.
  • The German data significantly contribute to the international ACROSTUDY project.