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Updated: Jun 20, 2026
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Transvaginal Mesh Insertion in the Ovine Model
Published on: July 27, 2017
Experimental comparison of meshes for rectal prolapse surgery
Cemil Calişkan1, A Denizli, O Makay
1Division of Proctology, Department of General Surgery, Ege University School of Medicine, Bornova, Izmir, Turkey. cemil.caliskan@ege.edu.tr
Summary
This study evaluated four mesh types for rectopexy in rats. While Ivalon mesh showed a higher foreign body reaction, all tested meshes were deemed suitable for posterior rectopexy.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Tissue Engineering
Background:
- Rectopexy is a surgical procedure to correct rectal prolapse.
- Mesh implantation is commonly used in rectopexy to provide structural support.
- The foreign body response to implanted meshes can influence surgical outcomes.
Purpose of the Study:
- To investigate the foreign body tissue reaction elicited by different mesh materials used in rectopexy.
- To compare the biocompatibility of four common mesh types: Surgipro, Ivalon, Gore-Tex, and Vypro.
Main Methods:
- Sixty rats were allocated into five groups, with four groups receiving mesh implantation (Surgipro, Ivalon, Gore-Tex, Vypro) in the retroperitoneal space.
- A sham group received no mesh implantation.
- After a 5-week observation period, specimens were assessed macroscopically and biochemically (tissue hydroxyproline and nitric oxide levels).
Main Results:
- The Ivalon mesh group exhibited the most pronounced foreign body reaction, indicated by significantly higher macroscopic adhesion scores (p < 0.005).
- No statistically significant differences were observed in tissue hydroxyproline and nitric oxide levels among the mesh groups (p > 0.05).
Conclusions:
- The study did not definitively identify a superior mesh type for rectopexy based on macroscopic, histological, or biochemical evaluations.
- The findings suggest that all four tested mesh types (Surgipro, Ivalon, Gore-Tex, Vypro) are suitable for implantation in posterior rectopexy procedures.
- Further research may be needed to clarify mesh selection criteria in rectal prolapse surgery.
