Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic and epigenetic characterization of paraventricular thalamic nucleus neurons in Polg1 mutant mice.

Neuroscience research·2026
Same author

Elucidating the Neural Basis of Bipolar Disorder - Secondary Publication.

JMA journal·2026
Same author

Real-world effectiveness of mono- and combination therapies of mood stabilisers and antipsychotics in bipolar disorder: nationwide, within-individual study of 315 046 patients.

The British journal of psychiatry : the journal of mental science·2026
Same author

Pathway-specific regulation of the paraventricular thalamic nucleus in depressive-like behavior.

Scientific reports·2026
Same author

Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same author

Required psychiatry rotation in residency training enhances psychiatric competence: A nationwide study in Japan.

Asian journal of psychiatry·2026
Same journal

Kynurenic Acid Offers Added Value in Predicting ECT Outcomes in Depression.

Neuropsychobiology·2026
Same journal

Decreased Specific Pavlovian-to-Instrumental Transfer Effect in Internet Gaming Disorder Following Short-Term Abstinence from Gaming.

Neuropsychobiology·2026
Same journal

Clinicians' Preferences and Attitudes Toward the Use of Lithium in the Treatment of Bipolar Disorders in Mexico.

Neuropsychobiology·2026
Same journal

Prevalence of psychotic symptoms and their clinical correlates in elderly major depressive disorder patients with subclinical hypothyroidism.

Neuropsychobiology·2026
Same journal

The Long- Term Course of Adolescent-Onset Major Depressive Disorder in Females: A 10-Year Cohort Study on Recurrence, Suicide Risk, and Service Use.

Neuropsychobiology·2026
Same journal

Evidence on Deliberate Self-Harm, Suicidal Ideation and Suicides in Pakistan: A Scoping Review of Methods, Contributing Factors and Associated Mental Disorders.

Neuropsychobiology·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Epigenomics in psychiatry.

Tadafumi Kato1

  • 1Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan. kato@brain.riken.jp

Neuropsychobiology
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Epigenetic factors, such as DNA methylation, may play a role in mental disorder development and treatment. Further epigenomic research is needed to understand these complex biological mechanisms.

More Related Videos

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

A Chromatin Assay for Human Brain Tissue
11:31

A Chromatin Assay for Human Brain Tissue

Published on: March 21, 2008

Related Experiment Videos

Last Updated: Jun 20, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

A Chromatin Assay for Human Brain Tissue
11:31

A Chromatin Assay for Human Brain Tissue

Published on: March 21, 2008

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The role of epigenetic factors in the pathophysiology of mental disorders remains largely unknown.
  • Potential mechanisms include epimutations during development, environmental influences, and epigenetic gene regulation in treatment response.

Purpose of the Study:

  • To explore the contribution of epigenetic factors to the development and progression of mental disorders.
  • To investigate the potential of epigenetics in understanding treatment mechanisms for mental health conditions.

Main Methods:

  • Analysis of DNA methylation differences in twins discordant for mental disorders.
  • Examination of DNA methylation in candidate genes in postmortem brain samples from patients and controls.
  • Genome-wide DNA methylation analysis in recent epigenomic studies.

Main Results:

  • Studies have detected DNA methylation differences between discordant twins and in candidate genes in patient brains.
  • Emerging epigenomic studies provide a broader view of DNA methylation patterns in mental disorders.

Conclusions:

  • Epigenetic mechanisms are increasingly implicated in the pathophysiology of mental disorders.
  • Comprehensive epigenomic analyses are crucial for elucidating the role of epigenetics in mental health and disease.