Epigenetic profiling in schizophrenia and major mental disorders
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Updated: Jun 20, 2026

A Chromatin Assay for Human Brain Tissue
Published on: March 21, 2008
Kazuya Iwamoto1, Tadafumi Kato
1Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan. kaziwamoto@brain.riken.jp
Abstract:
Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.
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