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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Papillary Dermis01:11

Papillary Dermis

Dermis
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Papillary Layer
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Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

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DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
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Classification of Epithelial Tissues: Overview

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Desmoplastic nevus: clinicopathologic keynotes.

Gerardo Ferrara1, Marcella Brasiello, Pietro Annese

  • 1Gaetano Rummo General Hospital, Benevento, Italy. gerardo.ferrara@libero.it

The American Journal of Dermatopathology
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

This study highlights key features of desmoplastic nevi. Identifying these dermoscopic and histopathologic patterns may define desmoplastic nevus as a distinct type of acquired melanocytic nevus.

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Area of Science:

  • Dermatology
  • Dermatopathology
  • Oncology

Background:

  • Acquired melanocytic nevi encompass a diverse range of lesions.
  • Desmoplastic nevus is a rare variant with specific histopathologic characteristics.
  • Distinguishing desmoplastic nevus from other melanocytic neoplasms is crucial for accurate diagnosis.

Observation:

  • The study details three cases of desmoplastic nevus.
  • Emphasis is placed on recurring dermoscopic features observed in these cases.
  • Repetitive histopathologic findings are also meticulously documented.

Findings:

  • Consistent dermoscopic and histopathologic features were identified across the three cases.
  • These specific features may serve as diagnostic markers for desmoplastic nevus.
  • The findings suggest potential for classifying desmoplastic nevus as a unique clinicopathologic entity.

Implications:

  • Confirmation in larger cohorts could establish desmoplastic nevus as a distinct entity.
  • Improved diagnostic criteria may enhance patient management and reduce misdiagnosis.
  • Further research into the spectrum of acquired melanocytic nevi is warranted.