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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Nanoshell-based substrates for surface enhanced spectroscopic detection of biomolecules
Carly S Levin1, Janardan Kundu, Aoune Barhoumi
1Department of Chemistry, Rice University, P.O. Box 1892, Houston, Texas 77251-1892, USA.
The Analyst
|August 18, 2009
Summary
Nanoshells, optically tunable nanoparticles, offer high-quality substrates for surface enhanced spectroscopies. Advances in nanoshell substrates improve the direct, spectroscopic detection of biomolecules with enhanced quality and selectivity.
Area of Science:
- Nanotechnology
- Spectroscopy
- Biomolecular detection
Background:
- Nanoshells are core-shell nanostructures with tunable optical properties.
- They support surface plasmons, creating enhanced electromagnetic fields.
- These properties make them suitable for sensitive detection applications.
Purpose of the Study:
- To outline the development of nanoshell-based substrates.
- To demonstrate their use for direct spectroscopic detection of biomolecules.
- To highlight recent advances improving substrate performance.
Main Methods:
- Utilizing the surface plasmon resonance of nanoshells.
- Developing nanoshell-based substrates for spectroscopy.
- Applying these substrates for biomolecular detection.
Main Results:
- Nanoshell substrates provide simple, scalable, and high-quality platforms.
- Demonstrated direct spectroscopic detection of biomolecules.
- Recent advances show improved spectroscopic quality, selectivity, and reproducibility.
Conclusions:
- Nanoshell-based substrates are effective for sensitive biomolecular detection.
- Advances in nanoshell technology enhance spectroscopic performance.
- These substrates offer a promising tool for various analytical applications.
