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Combined intraarterial and intravenous thrombolysis for severe cerebral venous sinus thrombosis

Xuanye Yue1, Gangming Xi, Zhiming Zhou

  • 1Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, 210002, Nanjing, Jiangsu Province, People's Republic of China.

Journal of Thrombosis and Thrombolysis
|August 18, 2009
PubMed

Insights

This study explored combined intra-arterial and intravenous thrombolysis for severe cerebral venous sinus thrombosis. The endovascular therapy showed promising results, improving neurological outcomes in most patients.

Area of Science:

  • Neurology
  • Interventional Radiology

Background:

  • Cerebral venous sinus thrombosis (CVST) is a serious condition requiring effective treatment.
  • Endovascular therapy offers a minimally invasive approach to managing CVST.

Observation:

  • A study examined six patients with severe CVST treated with combined intra-arterial and intravenous thrombolysis.
  • The procedure involved local thrombolysis with urokinase and intra-arterial infusion via the internal carotid artery.

Findings:

  • Complete recanalization was achieved in five out of six patients.
  • Five patients experienced complete clinical recovery (modified Rankin Scale score of 0).
  • One patient with delayed treatment died post-procedure.

Implications:

  • Combined endovascular thrombolysis appears to be a safe and effective treatment for severe CVST.
  • Early intervention with this technique may significantly improve patient outcomes.
  • Further research is warranted to confirm these findings in larger cohorts.

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