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Updated: Jun 20, 2026
09:03
A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
Silicone oil induced glaucoma: a review
Parul Ichhpujani1, Anjana Jindal, L Jay Katz
1Anna V. Goldberg Glaucoma Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA.
Summary
Silicone oil used for retinal detachment can cause secondary glaucoma through four main mechanisms. Understanding these causes helps in timely and appropriate treatment of this complication.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Glaucoma Research
Background:
- Silicone oil is a long-standing internal tamponade for complex retinal detachments.
- A significant complication of silicone oil use is the development of secondary glaucoma.
Purpose of the Study:
- To review the literature on silicone oil-induced secondary glaucoma.
- To clarify the pathogeneses, predisposing factors, and management strategies.
Main Methods:
- Literature review of secondary glaucomas related to silicone oil.
- Categorization of different types of silicone oil-induced glaucoma.
Main Results:
- Four distinct mechanisms contribute to silicone oil-induced glaucoma.
- These include mechanical obstruction, pupillary block, microdroplet-induced trabecular meshwork changes, and inflammation.
Conclusions:
- Identifying risk factors and understanding the pathogenesis of secondary glaucoma are crucial.
- This knowledge guides timely and effective treatment for silicone oil-induced ocular hypertension.
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