Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
Body Temperature01:07

Body Temperature

Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reclassification of Appendiceal Mucinous Neoplasms and Associated Pseudomyxoma Peritonei According to the Peritoneal Surface Oncology Group International Consensus: Clinicopathological Reflections of a Two-Center Cohort Study.

Annals of surgical oncology·2024
Same author

An Interprofessional Faculty Development Program for Workplace-Based Learning.

Perspectives on medical education·2024
Same author

The effect of air-free administration of intravenous drugs on microemboli during cardiopulmonary bypass.

Perfusion·2024
Same author

Does heparin rebound lead to postoperative blood loss in patients undergoing cardiac surgery with cardiopulmonary bypass?

Perfusion·2023
Same author

In pursuit of a better transition to selected residencies: a quasi-experimental evaluation of a final year of medical school dedicated to the acute care domain.

BMC medical education·2022
Same author

Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report.

Journal of medical case reports·2022

Related Experiment Video

Updated: Jun 20, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Atracurium during induced hyperthermia.

Gersten Jonker1, Leo J Hoogenboom, Bert van Ramshorst

  • 1Department of Pediatric Anesthesiology, Wilhelmina Children's Hospital, University Medical Centre, P.O. Box 85090, Utrecht 3508 AB, The Netherlands.

Journal of Anesthesia
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Hyperthermia increases atracurium clearance, potentially leading to inadequate neuromuscular block during surgery. Continuous monitoring of muscle relaxation is crucial in hyperthermic patients receiving atracurium.

More Related Videos

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Related Experiment Videos

Last Updated: Jun 20, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Oncology

Background:

  • Hyperthermic intraperitoneal chemotherapy (HIPEC) involves elevated body temperatures.
  • Atracurium is a neuromuscular blocking agent commonly used during surgery.
  • The Hofmann elimination of atracurium is known to be temperature-dependent.

Observation:

  • A patient undergoing HIPEC experienced partial recovery from neuromuscular block despite adequate surgical relaxation and continuous atracurium infusion.
  • This occurred in a hyperthermic state, contrasting with normothermic conditions.

Findings:

  • The observed recovery indicates significantly higher clearance of atracurium at elevated temperatures.
  • The temperature dependence of Hofmann elimination directly impacts atracurium's duration of action.

Implications:

  • Standard atracurium infusion rates may be insufficient to maintain neuromuscular block during HIPEC.
  • Close monitoring of neuromuscular function is essential in hyperthermic patients to ensure adequate anesthesia and surgical conditions.
  • This highlights the need for potential dose adjustments of atracurium in hyperthermic settings.