Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 20, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Biosensing with functionalized single asymmetric polymer nanochannels.

Mubarak Ali1, Birgitta Schiedt, Reinhard Neumann

  • 1Technische Universität Darmstadt, Fachbereich Material-u. Geowissenschaften, Fachgebiet Chemische Analytik, Petersenstrasse 23, D-64287 Darmstadt, Germany. m.ali@gsi.de

Macromolecular Bioscience
|August 18, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ion-Track-Etched Membranes as Nanoionic Platforms: Fabrication, Nanoscale Ion Transport, and Device Applications─A Review.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Multiple Negative Differential Resistances in Nanofluidic Conical Pores: A Phenomenological Model.

The journal of physical chemistry letters·2025
Same author

Neuromorphic responses of nanofluidic memristors in symmetric and asymmetric ionic solutions.

The Journal of chemical physics·2024
Same author

Correction to: Efficacy of Allopurinol in Improving Endothelial Dysfunction: A Systematic Review and Meta-Analysis.

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2023
Same author

Efficacy of Allopurinol in Improving Endothelial Dysfunction: A Systematic Review and Meta-Analysis.

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2023
Same author

Electrochemical impedance spectroscopy of membranes with nanofluidic conical pores.

Journal of colloid and interface science·2023
Same journal

AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy.

Macromolecular bioscience·2026
Same journal

A Novel Chitosan-Gelatin Scaffold and Cell Spray Therapy for Treating Limbal Stem Cell Deficiency.

Macromolecular bioscience·2026
Same journal

Electroconductive Soft Microcarriers for Suspension Culture of Skeletal Muscle Cells.

Macromolecular bioscience·2026
Same journal

Dual-Responsive Chitosan-Grafted PNIPAAm Hydrogel Eye Drop Incorporating Insulin-Imprinted Microgels for Dry Eye Syndrome Treatment.

Macromolecular bioscience·2026
Same journal

Levan Inspired Hybrid Composites Materials: Bridging Natural Polysaccharides with Biomedical Technology.

Macromolecular bioscience·2026
Same journal

Anion-Specific Mechanisms in Fibrinogen Self-Assembly: Contrasting Effects of Phosphates and Chlorides in Nanofiber Formation.

Macromolecular bioscience·2026
See all related articles

We covalently attached biotin to polyimide nanochannels for protein sensing. Surface charge modification enabled electrochemical detection of bovine serum albumin (BSA) via ionic current changes.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Protein detection is crucial in diagnostics and research.
  • Nanochannel-based sensors offer high sensitivity.
  • Surface functionalization is key for specific biomolecule capture.

Purpose of the Study:

  • To develop a method for direct covalent attachment of biotin to polyimide nanochannels.
  • To investigate the use of modified nanochannels for bio-specific protein sensing.
  • To explore surface charge reversal for electrochemical sensing of proteins.

Main Methods:

  • Direct covalent attachment of biotin to carboxyl groups on polyimide nanochannels.
  • Surface charge modification by converting carboxyl groups to amino groups.

More Related Videos

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

Related Experiment Videos

Last Updated: Jun 20, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

  • Electrochemical sensing of bovine serum albumin (BSA) using carboxylated and aminated channels.
  • Monitoring ionic current changes for biorecognition events.

    • Main Results:

    • Successful covalent immobilization of biotin onto polyimide nanochannels.
    • Demonstrated bio-specific sensing of protein analytes using biotinylated channels.
    • Achieved surface charge reversal from negative to positive via amination.
    • Quantified BSA detection through ionic current modulation in both negatively and positively charged channels.

    Conclusions:

    • Polyimide nanochannels can be effectively functionalized for protein recognition.
    • Surface charge engineering of nanochannels enhances their versatility for electrochemical biosensing.
    • Ionic current measurements in functionalized nanochannels provide a viable method for protein detection.