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Updated: Jun 20, 2026

Elucidating β-1,3-Glucanase and Peroxidase Physicochemical Properties of Wheat Cell Wall Defense Mechanism Against Diuraphis noxia Infestation
Published on: July 26, 2024
[Alpha-glucosidase inhibitors from Rubia cordifolia]
Wenyi Kang1, Li Zhang, Yanli Song
1Institute of Natural Products, Pharmaceutical College, Henan University, Kaifeng 475004, China. kangweny@hotmail.com
Objective:
To search alpha-glucosidase inhibitors from Rubia cordifolia.
Method:
The alpha-glucosidase inhibitors were isolated by the column chromatographic techniques and the bioassay-guided method in vitro. A combination of MS and NMR spectroscopy was used to identify the chemical structures. The inhibitory kinetics of the inhibitors were also investigated.
Result:
The chloroform extract showed high inhibitory activity, and three active compounds were isolated and identified as 1,3-dihydroxy-2-methylanthraquinone (1), 1-hydroxy-2-methylanthraquinone (2) and 1,2-dihydroxyanthraquinone (3). The IC5o values of compound 1-3 were all lower than that of acarbose. Compound 1 and 2 shown competitive type manner on alpha-glucosidase, whereas compound 3 shown noncompetitive type model.
Conclusion:
Compounds 1-3 as strong inhibitors of alpha-glucosidase were reported for the first time.
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